1. Inhibitory effects of gallic acid on the activity of exosomal secretory pathway in breast cancer cell lines: A possible anticancer impact

Nasrollah Jabbari , Maryam Feghhi, Omid Esnaashari, Hamid Soraya, Jafar Rezaie*

BioImpacts. 2022;12(6): 549-559. doi: 10.34172/bi.2022.23489

PMCID: PMC9809134 PMID: 36644548 Scopus ID: 85143387474

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Treatment of MCF-10a, MCF-7, and MDA-MD-231 cells with Gallic acid resulted in inhibition in the activity of the exosomal secretory pathway. Gallic acid can decrease the expression of genes involved in exosomes biogenesis (Alix and CD63) and secretion (Rab proteins). In addition, Gallic acid can change the expression of autophagy markers (LC3 and P62) in these cells. MVB: multivesicular body.

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2. Apoptotic effects of human amniotic fluid mesenchymal stem cells conditioned medium on human MCF-7 breast cancer cell line

Roghiyeh Pashaei-Asl , Maryam Pashaiasl, Esmaeil Ebrahimie, Maryam Lale Ataei, Maliheh Paknejad*

Bioimpacts. 2023;13(3): 191-206. doi: 10.34172/bi.2022.23813

PMCID: PMC10329748 PMID: 37431479 Scopus ID: 85171327177

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The application of hAFMSCs-CM, as a therapeutic reagent, can suppress breast cancer cells’ viabilities and induce apoptosis.

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